Organic Chemistry in Drug Discovery

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The role played by organic chemistry in the pharmaceutical industry continues to be one of the main drivers in the drug discovery process. However, the precise nature of that role is undergoing a visible change, not only because of the new synthetic methods and technologies now available to the synthetic and medicinal chemist, but also in several key areas, particularly in drug metabolism and chemical toxicology, as chemists deal with the ever more rapid turnaround of testing data that influences their day-to-day decisions.

Numerous changes are now occurring in the pharmaceutical industry, not just in the way that the industry is perceived, but also in the rapid expansion of biomedical and scientific knowledge, which affects the way science is practiced in the industry. The recent changes in the way that synthetic chemistry is practiced in this environment center around new scientific advances in synthetic techniques and new technologies for rational drug design, combinatorial chemistry, automated synthesis, and compound purification and identification. In addition, with the advent of high-throughput screening (HTS), we are now faced with many targets being screened and many hits being evaluated. However, success in this arena still requires skilled medicinal chemists making the correct choices, often with insight gleaned from interactions with computational chemists and structural biologists, about which “hits” (1) are likely to play out as true “lead” (1) structures that will meet the plethora of hurdles that any drug candidate must surmount. Download free Organic Chemistry in Drug Discovery here

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