Combinatorial Chemistry Technology

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Combinatorial Diversity in Nature 20 natural amino acids yield 400 dipeptides 8,000 tripeptides ... 64,000,000 hexapeptides and, in principle, 10400 proteins with MW ≈ 30 kD 100 chemically modified amino acids yield e.g. 1,000,000,000,000 hexapeptides, and ... 4 nucleic bases encode all organisms ! Principles of Combinatorial Chemistry Combinatorial Chemistry generates a multitude of chemically related (”congeneric”) compounds, so-called ”combinatorial libraries" In the last years, combinatorial chemistry in drug research changed more and more to automated parallel synthesis and parallel purification.

Combinatorial Chemistry Technology

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